Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Moderately Good
Based on 37 Reviews
7.9
Supplement Facts
Serving Size: 1 Capsule
Serving Per Container: 60
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
200 mg

Top Medical Research Studies

We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.

However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.

In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
Read More
This study focused on the potential protective effects of Coenzyme Q10 (CoQ10) against heart damage caused by copper toxicity. We induced myocardial injury in rats using daily doses of copper sulfate for a week, observing detrimental effects on heart function.

To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.

Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.

Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
Read More
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.

Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.

Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.

Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Read More

Most Useful Reviews

9
Cardiovascular improvement
20 people found this helpful
Good for the heart. This substance has cardioprotective, antiarrhythmic, and hypotensive effects. A large-scale Italian study involving 2664 patients with heart failure showed that long-term use of coenzyme Q10 reduced cyanosis in 78% and edema in 78.6%. Additionally, 63% experienced fewer arrhythmias, and 73% noticed reduced dizziness, with 54% reporting a decrease in multiple symptoms. A 2014 paper from Moscow State University indicated that coenzyme Q10 helped improve left ventricular ejection fraction, increased exercise tolerance, and normalised blood pressure in heart failure patients.
Read More
9
Palpitations ceased
15 people found this helpful
Great Product! I purchased this for heart reasons as I was experiencing frequent heart palpitations. After beginning this product, those palpitations have disappeared.
Read More
9
Rapid recovery noted
11 people found this helpful
Excellent! We chose this product at our doctor’s recommendation. My husband, who has kidney failure and heart issues, started taking Coenzyme Q10 post-surgery. Within 2-3 days, he began to feel significantly better and regained his strength. We are thrilled with the outcome and plan to order more.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
  • All Researches
We aimed to investigate the effects of Coenzyme Q10 (CoQ10) on heart health in the context of CDKL5 deficiency disorder (CDD). CDD is a complex condition caused by mutations in the CDKL5 gene, leading to severe developmental challenges and systemic issues, including oxidative stress.

Our study demonstrated that CoQ10 supplementation can significantly reduce harmful levels of reactive oxygen species (ROS) and help restore a balanced state of glutathione in the body. This is important because oxidative stress is believed to contribute to various health problems, including those affecting the heart.

Additionally, we found that CoQ10 not only improved markers of cellular health and proliferation in a human neuron model but also provided protective effects against lipid peroxidation and DNA damage in the hearts of a mouse model of CDD.

Overall, our findings suggest that CoQ10 may play a crucial role in alleviating oxidative stress and protecting heart health in individuals with CDD, offering a potential therapeutic avenue worth exploring further.
Read More
This study focused on the potential protective effects of Coenzyme Q10 (CoQ10) against heart damage caused by copper toxicity. We induced myocardial injury in rats using daily doses of copper sulfate for a week, observing detrimental effects on heart function.

To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.

Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.

Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
Read More
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.

Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.

Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.

Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Read More
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.

However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.

In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
Read More
9
CoQ10 mitigates chemotherapy-related heart damage
We aimed to explore the effects of Coenzyme Q10 (CoQ10) on heart health in the context of Doxorubicin treatment, a common chemotherapy known for its side effects, including heart damage. Our study involved 27 white albino rats, which we divided into three groups: one receiving CoQ10, another receiving Doxorubicin, and a final group receiving both treatments.

After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.

However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.

Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 37 Reviews
7.9
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Cardiovascular improvement
20 people found this helpful
Good for the heart. This substance has cardioprotective, antiarrhythmic, and hypotensive effects. A large-scale Italian study involving 2664 patients with heart failure showed that long-term use of coenzyme Q10 reduced cyanosis in 78% and edema in 78.6%. Additionally, 63% experienced fewer arrhythmias, and 73% noticed reduced dizziness, with 54% reporting a decrease in multiple symptoms. A 2014 paper from Moscow State University indicated that coenzyme Q10 helped improve left ventricular ejection fraction, increased exercise tolerance, and normalised blood pressure in heart failure patients.
Read More
9
Palpitations ceased
15 people found this helpful
Great Product! I purchased this for heart reasons as I was experiencing frequent heart palpitations. After beginning this product, those palpitations have disappeared.
Read More
9
Rapid recovery noted
11 people found this helpful
Excellent! We chose this product at our doctor’s recommendation. My husband, who has kidney failure and heart issues, started taking Coenzyme Q10 post-surgery. Within 2-3 days, he began to feel significantly better and regained his strength. We are thrilled with the outcome and plan to order more.
Read More
9
Enhanced vitality
6 people found this helpful
Coenzyme Q10 is a powerful antioxidant that supports cell regeneration and energy production, benefiting the heart primarily. After 40, our bodies produce insufficient amounts, thus supplementation is advisable. Regular intake can slow down overall bodily aging.
Read More
8.5
Youthful longevity
5 people found this helpful
Jarrow Formulas Coenzyme Q10 promotes healthy cardiovascular and immune system function, enhances cellular energy metabolism, and slows skin aging. As we age, the body's coenzyme levels drop, underlining its importance for overall metabolic health and energy production.
Read More

Frequently Asked Questions

9
Rapid recovery noted
11 people found this helpful
Excellent! We chose this product at our doctor’s recommendation. My husband, who has kidney failure and heart issues, started taking Coenzyme Q10 post-surgery. Within 2-3 days, he began to feel significantly better and regained his strength. We are thrilled with the outcome and plan to order more.
9
Healthy blood pressure
3 people found this helpful
Works great for heart health! After taking this for a few weeks, my blood pressure dropped by 10 to 15 points, landing me in a healthy range. Great!
10
Palpitations gone
1 people found this helpful
I experienced heart palpitations due to a faulty heart nerve, which my doctor suspects is a birth defect. After taking two of these daily, the palpitations have completely disappeared.
9
Stable health status
1 people found this helpful
I love Jarrow products! Their great quality and ingredients make a noticeable difference in my heart condition. After over 10 years of use, my health is stable, and I firmly believe in its benefits for my heart and skin, as well as my overall energy.
9
Cardiovascular improvement
20 people found this helpful
Good for the heart. This substance has cardioprotective, antiarrhythmic, and hypotensive effects. A large-scale Italian study involving 2664 patients with heart failure showed that long-term use of coenzyme Q10 reduced cyanosis in 78% and edema in 78.6%. Additionally, 63% experienced fewer arrhythmias, and 73% noticed reduced dizziness, with 54% reporting a decrease in multiple symptoms. A 2014 paper from Moscow State University indicated that coenzyme Q10 helped improve left ventricular ejection fraction, increased exercise tolerance, and normalised blood pressure in heart failure patients.
9
Palpitations ceased
15 people found this helpful
Great Product! I purchased this for heart reasons as I was experiencing frequent heart palpitations. After beginning this product, those palpitations have disappeared.
9
Energy boost
2 people found this helpful
This is my favourite health supplement! After several years of use, my heart problems have vanished, and I now have much more energy. I take 100 mg daily, and if I'm feeling unwell or under stress, I take two at once. I often say, if you want to live longer, anyone who drinks this will never die! 😉
9
Significant improvement
4 people found this helpful
Highly recommended! CoQ10 is known to enhance a variety of diseases. I administered over 1,200mg/day to my elderly mother for three years until her health improved. I take two capsules daily. If you have serious health issues, it’s worth trying CoQ10 alongside B vitamins and protein.
7.5
Improved energy level
11 people found this helpful
Protection with Statins. If you're on statins for cholesterol, it's essential to take 200 mg of Coenzyme Q10 to reduce energy loss. Before starting, I struggled to walk around my flat, but now I feel revitalised, thanks to Jarrow Formulas.
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.

Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.

Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.

Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
4
Ubiquinone shows mixed heart surgery effects
In our exploration of how coenzyme Q10, also known as ubiquinone, affects outcomes for patients undergoing cardiac surgery, we analyzed its potential benefits in preventing acute kidney injury (AKI). This condition is a significant concern, impacting nearly half of the patients after heart surgery due to factors like ischemia-reperfusion injury and oxidative stress.

For this study, we compared a group of patients who received high doses of ubiquinone—8 mg per kg per day, divided into three doses—with a control group given a placebo. While the intervention did not lead to a significant reduction in the incidence of cardiac surgery-related acute kidney injury, we noted some interesting secondary outcomes. Patients who took ubiquinone experienced less postoperative bleeding and lower levels of a specific heart protein (hs-TnI) indicating less heart damage.

Although ubiquinone didn’t demonstrate a clear advantage in preventing kidney injury, its effect on reducing postoperative bleeding and heart stress markers suggests there may still be beneficial aspects worth further exploration. This study provides a foundation for considering how coenzyme Q10 might play a role in enhancing recovery after heart surgery, even if its effects on kidney injury were not significant.

References

  1. Loi M, Valenti F, Medici G, Mottolese N, Candini G, et al. Beneficial Antioxidant Effects of Coenzyme Q10 in In Vitro and In Vivo Models of CDKL5 Deficiency Disorder. Int J Mol Sci. 2025;26. doi:10.3390/ijms26052204
  2. Vučemilović H, Kovač R, Stanišić L, Sanader Vučemilović A, Mrčela D, et al. Is High-Dose Ubiquinone Therapy Before Cardiac Surgery Enough to Reduce the Incidence of Cardiac Surgery-Associated Acute Kidney Injury? A Randomized Controlled Trial. Antioxidants (Basel). 2025;14. doi:10.3390/antiox14020243
  3. Alghibiwi HK, Alhusiani AM, Sarawi WS, Fadda L, Alomar HA, et al. Coenzyme Q10 and its liposomal form prevent copper cardiotoxicity by attenuating oxidative stress, TLR-4/NF-κB signaling and necroptosis in rats. Cell Mol Biol (Noisy-le-grand). 2025;71:118. doi:10.14715/cmb/2025.70.1.13
  4. Zhang M, Sun MY, He WY, Yu SF, Ma WC. [Experimental study on the treatment of diabetic cardiomyopathy in rats by using ultrasound-targeted microbubble destruction combined with coenzyme Q10 loaded long-circulating nanoliposomes]. Zhonghua Yi Xue Za Zhi. 2024;104:3765. doi:10.3760/cma.j.cn112137-20240605-01273
  5. Xu J, Xiang L, Yin X, Song H, Chen C, et al. Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 2024;24:592. doi:10.1186/s12872-024-04232-z
  6. Guo Z, Tian Y, Liu N, Chen Y, Chen X, et al. Mitochondrial Stress as a Central Player in the Pathogenesis of Hypoxia-Related Myocardial Dysfunction: New Insights. Int J Med Sci. 2024;21:2502. doi:10.7150/ijms.99359
  7. Qazi SU, Bin Naeem MA, Umar M, Zahid MJ, Kan Changez MI, et al. Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis. Future Cardiol. 2024;20:221. doi:10.1080/14796678.2024.2352308
  8. Intan RE, Balti DR, Nugraha RA, Alkaff FF, Salamah S, et al. Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report. J Pak Med Assoc. 2024;74:S81. doi:10.47391/JPMA.S6-ACSA-16
  9. Ali S, Sulaiman E, Dhiaa S. HISTOLOGICAL EFFECTS OF CO ENZYME Q10 ON DOXORUBICIN-INDUCED DEFICITS OF CARDIOPULMONARY AXIS IN WHITE ALBINO RATS. Georgian Med News. 2024.
  10. Alehagen U, Aaseth J, Schomburg L, Larsson A, Opstad T, et al. Selenoprotein P increases upon selenium and coenzyme Q supplementation and is associated with telomere length, quality of life and reduced inflammation and mortality. Free Radic Biol Med. 2024;222:403. doi:10.1016/j.freeradbiomed.2024.06.027
  11. Zeng M, Chen Z, Zhang Y, Pang Y. Combination of trimetazidine and coenzyme Q10 for the treatment of acute viral myocarditis: a systematic review and meta-analysis. J Infect Dev Ctries. 2024;18:658. doi:10.3855/jidc.18776
  12. Du H, Zhao Y, Wen J, Dai B, Hu G, et al. LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1. Circulation. 2024;150:1030. doi:10.1161/CIRCULATIONAHA.123.067861
  13. Graczyk P, Dach A, Dyrka K, Pawlik A. Pathophysiology and Advances in the Therapy of Cardiomyopathy in Patients with Diabetes Mellitus. Int J Mol Sci. 2024;25. doi:10.3390/ijms25095027
  14. Alehagen U, Alexander J, Aaseth JO, Larsson A, Opstad TB. Supplementation with selenium and coenzyme Q in an elderly Swedish population low in selenium - positive effects on thyroid hormones, cardiovascular mortality, and quality of life. BMC Med. 2024;22:191. doi:10.1186/s12916-024-03411-1
  15. Antar SA, Abdo W, Helal AI, Abduh MS, Hakami ZH, et al. Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-κB/NLRP3 inflammasome axis and attenuating oxidative stress in mice. Life Sci. 2024;348:122688. doi:10.1016/j.lfs.2024.122688
  16. Seo JS. Chronological change of left ventricular global longitudinal strain in patients with maternally inherited diabetes and deafness: A case series. Medicine (Baltimore). 2024;103:e37447. doi:10.1097/MD.0000000000037447
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